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David Wallace Laboratory

Lab Location/ Complete Address:

Room E-363

Oklahoma State University Center for Health Sciences

1111 West 17th Street

Tulsa, Oklahoma 74107


Lab Lead Contact:

Dr. David R Wallace, PhD

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Lab Personnel:

T.B.A Manager;

Research Facilities and Regulatory Compliance




Research Description:

Molecular Interactions between HIV proteins and the dopamine transporter will provide insight into gender-related differences in AIDS-related central nervous system disorders leading to potential gender-specific treatment strategies for HIV and cocaine addiction. Effects of trace environmental toxin exposure on CNS activity with emphasis on dopaminergic function. The rationale for these studies is that low-level exposure to environmental toxins may not cause visible CNS effects until later which would have implications for forensic analysis and determining the potential cause of CNS damage.

Isolation and characterization of naturally-occurring, novel CNS-acting compounds drug discovery and development. This program investigates the use of naturally occurring compounds as centrally acting agents. One series of studies has been examining the effects of Native American plants indigenous to Oklahoma and their potential analgesic effects. A second series is investigating the estrogenic effects of flavonoids found in soy and flaxseed.


Instrument and Technique Specialties:

1) Cell Culture

2) High Performance Liquid Chromatography

3) Neuroanatomy

4) Neurotoxicology

5) Cellular neurochemical assays

6) Radioligand binding

7) Neurotransmitter release/uptake

8) Research Design and Analysis


Funding Sources:

National Institutes of Health

Oklahoma Tobacco Research Center

Intramural Funds (OSU-CHS)

Our Contact Details

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Our Mission:

To develop bioscience research in Tulsa and to position Tulsa to be a leader in bioscience education, training, research and innovation by utilizing the assets of all area institutions of higher education.