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Kyeorda Kemp Laboratory

 

Lab Location/ Complete Address: 

Northeastern State Univiersity 

Natural Sceince Department

3100 New Orleans St.

Broken Arrow, OK. 74014

 

Lab Lead Contact:

Dr. Kyeorda Kemp

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Lab Personnel:

Webpage:
https://academics.nsuok.edu/naturalsciences/FacultyResearch/DrKyeordaKemp.aspx

 

Research Description:

 Modifications that occur in cells, such as activation, can lead to a “backlog” of unfolded proteins in the endoplasmic reticulum (ER), and the cell has to resolve this in order to avoid apoptosis. We have recently identified a link between the pathways that resolves the accumulation of unfolded protein, the unfolded protein response (UPR), and the secretion of TH2 cytokines. We have a number of projects in the lab related to UPR and immune response.

  1. We are currently studying how the UPR promotes TH2 cytokine production with a focus on cell signaling pathways. Th2 cells play an important role is resolved extracellular infections, but themselves can become pathogenic when overactivated as in the case of asthma and allergy. Therefore, exploring how UPR regulates TH2 cells will allow us to develop new drug therapies for treatment of TH2 mediated diseases.
  2. Recent studies have found a role for UPR in response to abiotic (heat, salt, etc.) and biotic (disease) stressors. Watermelon are an important cash crop in Oklahoma, and viral diseases are a major cause of reduced yields. We are currently using RNA sequencing to determine if UPR and immune related gene regulation is altered in watermelon crops infected with viruses.
  3. We have identified additional molecules involved in UPR response that are deferentially regulated in various subsets of T cells using primary mouse cell culture. We are currently confirming these results using human T cells and hope to begin knockout studies of these molecules soon.
    Our long-term goal with regards to mammalian immunology is to develop better therapeutic agents for use in diseases where T cells are performing inappropriately by identifying molecules that regulate T cell functions. Our long-term goal with regards to plant immunology is to identify ways to protect plants against abiotic and biotic stressors.

Teaching Research: Self corrections of assessment have long been touted as a way to improve student learning of material and are accepted by many as a best practice in teaching. However, there is some debate on whether self corrections of assessment improves student learning. I am currently investigating the role of self test corrections in student mastery of material in an introductory level biology course.

 

Funding Sources currently:

OK EPScoR, Northeastern State University Faculty Research Council, and Oklahoma INBRE

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Our Mission:

To develop bioscience research in Tulsa and to position Tulsa to be a leader in bioscience education, training, research and innovation by utilizing the assets of all area institutions of higher education.
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