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Rashmi Kaul Laboratory

Lab Location/ Complete Address:

OSU-CHS Campus Immunology Lab,

Biochemistry and Microbiolgy Department

Room #318 and #319 Barson Building

 

Lab Lead Contact:

Rashmi Kaul, Ph.D.

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Webpage:

http://www.healthsciences.okstate.edu/college/biomedical/bio_micro/kaul.cfm

 

Research Description:

My laboratory investigates the role of estrogen and estrogen receptors in regulation of immunity and inflammation during infectious disease development or chronic infectious disease induced cancer development. Over the past several years we have been working on understanding Dr fimbriae E. coli induced urinary tract infection disease pathogenesis and Hepatitis C virus induced liver disease pathogenesis leading to cancer development. Hepatitis C virus (HCV) infection is the prime cause of rising incidence of Hepatoatocellular carcinoma (HCC) in the United States. The chronic sequel of HCV infection includes progressive hepatic fibrosis, cirrhosis and HCC. Recent reports suggest that estrogen levels and estrogen receptor status play an important role in HCV disease pathogenesis. We have established in vitro and in vivo disease models to understand estrogen regulated host immune defenses against E. coli and Hepatitis C virus. Our lab is also studying the role of estrogen in endometrial cancer development.

 

Instrument and Technique Specialties:

In vitro assays : Cell culture, Tissue culture, Bacterial invasion assay, Immunoassays, Immunohistochemistry, Westernblotting, Flowcytometry, Molecular Biology techniques (DNA extraction, RNA extraction, Real -Time RTPCR on Step one Real Time PCR System), Kinase activation assays on cell and tissue extracts.

In vivo assays: Animal model handling, Animal model of urinary tract infection, Animal model of Pre-term labor due to urinary tract infection.

 

Funding Sources:

Cancer Sucks, Bixby Oklahoma

OSU-CHS Intramural Grants

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Our Mission:

To develop bioscience research in Tulsa and to position Tulsa to be a leader in bioscience education, training, research and innovation by utilizing the assets of all area institutions of higher education.
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